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Publications

2024

Discovery of Thioether-Cyclized Macrocyclic Covalent Inhibitors by mRNA Display 

Tong Lan, Cheng Peng, Xiyuan Yao, Rachel Shu Ting Chan, Tongyao Wei, Anuchit Rupanya, Aleksandar Radakovic, Sijie Wang, Shiyu Chen, Scott Lovell, Scott A. Snyder, Matthew Bogyo, Bryan C. Dickinson 

Cell Chemical Biology: 10.1016/j.chembiol.2024.07.006

Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets

John M Bennett, Sunil K Narwal, Stephanie Kabeche, Daniel Abegg, Fiona Hackett, Tomas Yeo, Veronica L Li, Ryan K Muir, Franco F Faucher, Scott Lovell, Michael J Blackman, Alexander Adibekian, Ellen Yeh, David A Fidock, Matthew Bogyo

Cell Chemical Biology: 10.1016/j.chembiol.2024.07.006

2023

Novel antimicrobial strategies to treat multi‐drug resistant Staphylococcus aureus infections

​Edward JA Douglas, Sri W Wulandari, Scott D Lovell, Maisem Laabei

Microbial biotechnology: 10.1111/1751-7915.14268

Solid phase synthesis of fluorosulfate containing macrocycles for chemoproteomic workflows

Franco F Faucher, Daniel Abegg, Phillip Ipock, Alexander Adibekian, Scott Lovell, Matthew Bogyo

Israel Journal of Chemistry: 10.1002/ijch.202300020

2022

A KLK6 activity-based probe reveals a role for KLK6 activity in pancreatic cancer cell invasion

Leran Zhang, Scott Lovell, Elena De Vita, Pravin Kumar Ankush Jagtap, Daniel Lucy, Andrea Goya Grocin, Svend Kjær, Annabel Borg, Janosch Hennig, Aubry K Miller, Edward W Tate

Journal of the American Chemical Society: 10.1021/jacs.2c07378

2021

Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1

Thomas Kryza*, Tashbib Khan*, Scott Lovell*, Brittney S Harrington, Julia Yin, Sean Porazinski, Marina Pajic, Hannu Koistinen, Juha K Rantala, Tobias Dreyer, Viktor Magdolen, Ute Reuning, Yaowu He, Edward W Tate, John D Hooper

Nature Chemical Biology: 10.1038/s41589-021-00783-w

A suite of activity-based probes to dissect the KLK activome in drug-resistant prostate cancer

Scott Lovell, Leran Zhang, Thomas Kryza, Anna Neodo, Nathalie Bock, Elena De Vita, Elizabeth D Williams, Elisabeth Engelsberger, Congyi Xu, Alexander T Bakker, Maria Maneiro, Reiko J Tanaka, Charlotte L Bevan, Judith A Clements, Edward W Tate

Journal of the American Chemical Society: 10.1021/jacs.1c03950

Identification of highly selective covalent inhibitors by phage display

Shiyu Chen, Scott Lovell, Sumin Lee, Matthias Fellner, Peter D Mace, Matthew Bogyo

Nature Biotechnology: 10.1038/s41587-020-0733-7

Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19

Kas Steuten, Heeyoung Kim, John C Widen, Brett M Babin, Ouma Onguka, Scott Lovell, Oguz Bolgi, Berati Cerikan, Christopher J Neufeldt, Mirko Cortese, Ryan K Muir, John M Bennett, Ruth Geiss-Friedlander, Christoph Peters, Ralf Bartenschlager, Matthew Bogyo

ACS Infectious Diseases: 10.1021/acsinfecdis.0c00815

2020

Strategies for tuning the selectivity of chemical probes that target serine hydrolases

Franco Faucher, John M Bennett, Matthew Bogyo, Scott Lovell

Cell Chemical Biology: 10.1016/j.chembiol.2020.07.008

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

Bruno M Simões, Angélica Santiago-Gómez, Chiara Chiodo, Tiago Moreira, Daniel Conole, Scott Lovell, Denis Alferez, Rachel Eyre, Katherine Spence, Aida Sarmiento-Castro, Bertram Kohler, Ludivine Morisset, Marilena Lanzino, Sebastiano Andò, Elisabetta Marangoni, Andrew H Sims, Edward W Tate, Sacha J Howell, Robert B Clarke

Oncogene: 10.1038/s41388-020-1335-z

Faecal neutrophil elastase-antiprotease balance reflects colitis severity

Rachael Barry, David Ruano-Gallego, Shiva T Radhakrishnan, Scott Lovell, Lu Yu, Olga Kotik, Izabela Glegola-Madejska, Edward W Tate, Jyoti S Choudhary, Horace RT Williams, Gad Frankel

Mucosal Immunology: 10.1038/s41385-019-0235-4

The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer

Thomas Kryza, Nathalie Bock, Scott Lovell, Anja Rockstroh, Melanie L Lehman, Adam Lesner, Janaththani Panchadsaram, Lakmali Munasinghage Silva, Srilakshmi Srinivasan, Cameron E Snell, Elizabeth D Williams, Ladan Fazli, Martin Gleave, Jyotsna Batra, Colleen Nelson, Edward W Tate, Jonathan Harris, John D Hooper, Judith A Clements

Molecular Oncology: 10.1002/1878-0261.12587

2019

Chemical Probes for Proteins and Networks

Scott Lovell, Charlotte L Sutherell, Edward W Tate

Mass Spectrometry‐Based Chemical Proteomics: 978-1-118-97020-1

2018

Depsipeptides featuring a neutral P1 are potent inhibitors of kallikrein-related peptidase 6 with on-target cellular activity

Elena De Vita, Peter Schüler, Scott Lovell, Jasmin Lohbeck, Sven Kullmann, Eitan Rabinovich, Amiram Sananes, Bernd Heßling, Veronique Hamon, Niv Papo, Jochen Hess, Edward W Tate, Nikolas Gunkel, Aubry K Miller

Journal of Medicinal Chemistry: 10.1021/acs.jmedchem.8b01106

2013

Novel and versatile synthesis of disubstituted 1, 2-dihydro-1, 2, 4-triazol-3-ones

Mark A Graham, Paul A Bethel, Jonathan Burgess, Gary Fairley, Steve C Glossop, Ryan DR Greenwood, Clifford D Jones, Scott Lovell, Steve Swallow

Organic Letters: 10.1021/ol402920z

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